Hypoxia-inducible Factor 1 (HIF-1 )-mediated Hypoxia Increases BACE1 Expression and -Amyloid Generation*
نویسندگان
چکیده
Xian Zhang, Kun Zhou, Ruishan Wang, Jiankun Cui, Stuart A. Lipton, Francesca-Fang Liao, Huaxi Xu, and Yun-wu Zhang From the Institute for Biomedical Research and School of Life Sciences, Xiamen University, Xiamen 361005, China, the Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, and the Burnham Institute for Medical Research, La Jolla, California 92037
منابع مشابه
Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells.
Hypoxia which is mainly mediated by hypoxia-inducible factor 1 (HIF-1), can greatly contribute to the occurrence of Alzheimer's disease (AD) by increasing beta-site APP cleaving enzyme (BACE1) gene expression, protein level and beta-secretase activity, resulting in a significant generation of amyloid-beta (Abeta). Salidroside has been reported to have great neuroprotective effects. The aim of t...
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